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We highly value multidisciplinary team science to improve public health!

Epignetics & Tobacco

Biological Effects of Emerging Tobacco Products, including E-Cigarettes

The pulmonary effects of a standardized research E-cigarette: Protonated Nicotine Effects

  • TheOSU Intramural Research Program (Idea Grant), MPI

  • The goal is to evaluate the lung toxicity of electronic cigarettes by switching from cigarettes to electronic cigarettes with and without nicotine

Mitochondrial genetic alterations: a clinical trial of a standardized research E-cigarette

  • NIH/National Heart, Lung, and Blood Institute (NHLBI R21HL147401), PI 

  • The goal is to establish the use of bronchoscopic evaluation of mitochondrial DNA for future studies assessing specific electronic cigarette designs and to provide a non-invasive method through nasal brushings for mitochondrial DNA as a biomarker of harm

Nasal inflammation as a surrogate for lung inflammation of smokers and E-cigarette users

  • OSU’ CCTS Core Service Award, PI

  • The goal of this study is to assess nasal fluids as a surrogate marker for lung inflammation in relation to smoking and electronic cigarette use.

Biological Effects of Flavored Tobacco Products, including Menthol

Epigenetic aging among homeless youth with menthol smoking in relation to brain injury

  • The Ohio State University Chronic Brain Injury (CBI) Program Pilot Award, MPI

  • The goal is to assess executive function dysregulation, develop an appropriate intervention component to pair with evidence-based smoking cessation, and understand the role of epigenetic aging among youth experiencing homelessness

Epigenetic aging among African American smokers of menthol cigarettes

  • OSU College of Public Health, Rasism internal grant, MPI

  • The goal is to assess the biological effects of menthol cigarettes among African Americans menthol cigarette smokers when they switch to other tobacco products

Epignetics & Diseases

Effects of E-cigarettes on allergic airway diseases

  • The goal of this study is to access pulmonary effects of electronic cigarette use in asthmatic mice models

Epigenetic cancer etiology and development in structural firefighters

  • NIH/National Institute for Occupational Safety and Health R01, co-I

  • The goal is to investigate an association of cumulative occupational wildland firefighters with adverse molecular (e.g., DNA methylation) and functional changes in the respiratory airways

DNA Methylation as efficacy biomarkers for Immunotherapy 

  • The OSU CCTS-NIH KL2, PI

  • The goal is to obtain new skills and learn to conduct clinical/translational research using DNA methylation as efficacy biomarkers for immunotherapy in lung cancer patients who are smokers, former smokers, and never-smokers 

Other Epignetic studies

Epigenetic variations in the multiethnic cohort (MEC)

  • NCI U01 Supplement grant, co-I (subaward PI)

  • The goal of this study is to conduct a genome-wide and targeted DNA methylation study in relation to metabolic-diseases-related blood biomarkers, and cancer risk factors to provide biological insights regarding epigenetic predisposition

Modeling-based omics data integration for lung epigenetic aging

  • The goal of this study is to implement statistical modeling approaches to evaluate complex biological features as indicators of biological aging measured by DNA methylation on the lungs

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